Oligolysine-based saccharide clusters: synthesis and specificity
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چکیده
منابع مشابه
Oligolysine-based saccharide clusters: synthesis and specificity.
In search of specific and highly selective sugar clusters for cell receptors, such as membrane lectins, various disaccharides were coupled to small peptide cores through an amide bond. In a first step, the reducing disaccharides, i.e. lactose and three different dimannoses, were converted into glycosyl-pyroglutamyl-beta-alanine derivatives. The free carboxylic group of these conjugates was then...
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Dendritic cells are potent antigen-presenting cells that express several membrane lectins, including the mannose receptor and DC-SIGN (dendritic cell-specific ICAM-3-grabbing nonintegrin). To identify highly specific ligands for these dendritic cell receptors, oligosaccharides were converted into glycosynthons (Os) and were used to prepare oligolysine-based glycoclusters, Os-[Lys(Os)]n-Ala-Cys-...
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The complexes [MoS (CUNCS) ] w hen x = 2,3,4 and [MoOS , (CUNCS) ] when y = 2, 3 have been prepared by the reaction of CuSCN with [P(C H ) ] [MoS ] or [P(C H ) ] [MOOS ] in dry degassed acetone or DMFsolution and recrystallized from dichloromethane, the attempted preparation of [MoS (AgSCN) ] and [MOOS (AgSCN) ] failed. The Raman, IR, UV/VIS, C-nmr and Mo-nmr spectra of the co...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2002
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20020673